The applicability of conventional cytotoxicity assays to predict safety/toxicity of mesoporous silica nanoparticles, silver and gold nanoparticles and multi-walled carbon nanotubes
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- 作者：Marika Mannerströ ; ma ; marika.mannerstrom@uta.fi" class="auth_mail" title="E-mail the corresponding author ; Jing Zoub ; c ; Tarja Toimelaa ; Ilmari Pyykkö ; b ; Tuula Heinonena
- 关键词：AgNPs ; silver nanoparticles ; AuNPs ; gold nanoparticles ; BET ; Brunauer ; Emmett and Teller method ; DLS ; dynamic light scattering ; DMEM ; Dulbecco's Modified Eagle's Medium ; DW ; deionized water ; ENMs ; engineered nanomaterials ; FBS ; fetal bovine serum ; GLP ; good laboratory practice ; MSNPs ; mesoporous silica nanoparticles ; MWCNTs ; multi-wall carbon nanotubes ; NBCS ; newborn calf serum ; NRU ; neutral red uptake ; OECD ; Organization for Economic Cooperation and Development ; PVP ; polyvinylpyrrolidone ; RPMI
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：37
- 期：Complete
- 页码：113-120
- 全文大小：430 K
文摘
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AgNPs were toxic to all cell types, MWCNTs were toxic only to macrophages.
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Macrophages discovered cytotoxicity that was not captured by fibroblasts.
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AuNPs and MSNPs were least toxic to all cell types.
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Nanoparticle toxicity to fibroblasts was ranked similarly by WST-1 and NRU.
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Conventional cytotoxicity assays can be applied in ENM testing with caution.