Progress on materials and scaffold fabrications applied to esophageal tissue engineering

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• 作者：Qiuxiang Shen ; Peina Shi ; Mongna Gao ; Xuechan Yu ; Yuxin Liu ; Ling Luo ; Yabin Zhu ; ^{zhuyabin@nbu.edu.cn}
• 关键词：Esophageal tissue engineering ; Materials ; Scaffold fabrication ; Research progress
• 刊名：Materials Science and Engineering: C
• 出版年：2013
• 出版时间：1 May, 2013
• 年：2013
• 卷：33
• 期：4
• 页码：1860-1866
• 全文大小：1364 K

文摘

The mortality rate from esophageal disease like atresia, carcinoma, tracheoesophageal fistula, etc. is increasing rapidly all over the world. Traditional therapies such as surgery, radiotherapy or chemotherapy have been met with very limited success resulting in reduced survival rate and quality of patients' life. Tissue-engineered esophagus, a novel substitute possessing structure and function similar to native tissue, is believed to be an effective therapy and a promising replacement in the future. However, research on esophageal tissue engineering is still at an early stage. Considerable research has been focused on developing ideal scaffolds with optimal materials and methods of fabrication. This article gives a review of materials and scaffold fabrications currently applied in esophageal tissue engineering research.