The impact of motor and depressive symptoms on quality of life in patients with Parkinson's disease

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• 作者：Jiin-Ling Jiang ; Sheng-Tzung Tsai ; Tsung-Cheng Hsieh ; Chi-Wei Lee ; Sheng-Huang Lin ; Shin-Yuan Chen
• 关键词：Depression ; Parkinson's disease ; Quality of life
• 刊名：Tzu Chi Medical Journal
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：25
• 期：3
• 页码：175-178
• 全文大小：206 K

文摘

Objective

To identify factors that affect the quality of life (QoL) of patients with idiopathic Parkinson's disease (IPD).

Materials and Methods

Twenty-seven IPD patients from Hualien Tzu Chi Hospital were enrolled between May, 2008 and July, 2012. All patients completed a Parkinson's disease-specific QoL questionnaire and the Beck Depression Inventory (BDI). A structured questionnaire interview and complete neurological examination, including the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS part III), the Schwab and England Disability Scale (S & E), the Hoehn and Yahr Scale, and the Mini-Mental State Examination (MMSE) were administered by a nurse and a neurologist.

Results

The degree of depression and severity of disease were significantly correlated with the QoL of IPD patients (r?=?0.49, p?=?0.01, and r?=?0.44, p?=?0.02, respectively). The UPDRS part III, S & E, and MMSE scores did not correlate significantly with QoL scores (r?=?0.22, p?=?0.26, r?=??0.36, p?=?0.06, and r?=??0.25, p?=?0.22, respectively). The BDI-¢òdepression score accounted for 31.5 % of the variance of the QoL scores.

Conclusion

Depression and disease severity have significant impacts on the QoL of IPD patients. Treatment profiles should encompass both motor and non-motor domains.