L'hypothermie thérapeutique

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• 作者：B. Vigué ; T. Geeraerts ; M. Le Guen ; N. Engrand and C. Ract
• 关键词：Hypothermia ; Fever ; Head injury ; Cerebral ischemia ; Intracranial pressure
• 刊名：Annales Francaises d'Anesthesie et de Reanimation
• 出版年：2006
• 出版时间：August 2006
• 年：2006
• 卷：25
• 期：8
• 页码：838-844
• 全文大小：367 K

文摘

The benefit of therapeutic hypothermia after severe head injury is highly controversial. However, hypothermia is still used and studied in this context for multiple reasons. Efficacy of hypothermia is demonstrated after cerebral ischemia in numerous animal studies and after cardiac arrest in human studies. Hyperthermia is a major independent factor of outcome after cerebral ischemic or traumatic brain injury. Moreover, ICP is related to core temperature, and hypothermia may be used to decrease intracranial hypertension. However, many questions are still unresolved and can explain discrepancies between clinical studies: direct measurement of cerebral temperature, relationship between ICP, temperature and PaCO₂, level and duration of hypothermia and precise methods for cooling and particularly for rewarming.