刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:February 2017
年:2017
卷:1861
期:2
页码:246-255
全文大小:750 K
卷排序:1861
文摘
Two novel splicing variants of human PDYN mRNA have been identified. A novel ∆ SP-PDYN splicing variant is mostly expressed in human striatum. ∆ SP-PDYN protein lacks a fragment of signal peptide (SP). ∆ SP-PDYN is not processed to mature dynorphins but targeted to the cell nuclei in a model cellular system. Unprocessed, likely ∆ SP-PDYN is localized in neuronal nuclei in human striatum.