Methionine enkephalin (MENK) mounts antitumor effect via regulating dendritic cells (DCs)

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• 作者：Yiming Meng^a ; ^b ; Xinghua Gao^c ; Wenna Chen^d ; Nicolas P. Plotnikoff^e ; Noreen Griffin^e ; Guirong Zhang^b ; Fengping Shan^a ; ^{fpshan@cmu.edu.cn}
• 关键词：Methionine enkephalin (MENK) ; Bone marrow-derived dendritic cells (BMDCs) ; Opioid receptor ; Antitumor ; Immunoregulation
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：61-71
• 全文大小：1546 K
• 卷排序：44

文摘

It is the first time that published article elucidates MENK mounts anti-tumor effect via regulating dendritic cells. MENK activated DCs increase in TLR4 and MyD88-NF-kB expression and secret higher levels of a spectrum of cytokines. MENK activated DCs exerts antitumor activity mainly through driving T cells.