Development and validation of Raman spectroscopic classification models to discriminate tongue squamous cell carcinoma from non-tumorous tissue
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- 作者：Froukje L.J. Cals<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>f.cals@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; Senada Koljenović<sup>csup><sup> ; sup><sup>s.koljenovic@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; José ; A. Hardillo<sup>asup><sup> ; sup><sup>j.hardillo@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; Robert J. Baatenburg de Jong<sup>asup><sup> ; sup><sup>r.j.baatenburgdejong@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; Tom C. Bakker Schut<sup>bsup><sup> ; sup><sup>t.bakkerschut@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; Gerwin J. Puppels<sup>bsup><sup> ; sup><sup>g.puppels@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Raman spectroscopy ; Oral cancer ; Oral cavity squamous cell carcinoma ; Adequate resection margins ; Tissue classification model ; Tumor versus non-tumorous tissue ; Intra-operative assessment
- 刊名：Oral Oncology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：41-47
- 全文大小：1103 K
文摘
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Inadequate resection margins are a huge problem in OCSCC surgery.
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Raman spectroscopy is an optical technique suitable for tissue characterization.
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Our Raman spectroscopic classification models discriminate OCSCC from non-tumor.
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The models were validated and showed high sensitivity and specificity.
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The clinical relevance of the models was discussed.