Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes
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- 作者：Mako Yasudaa ; Yuki Tanakaa ; Shinji Kumea ; skume@belle.shiga-med.ac.jp" class="auth_mail ; Yoshikata Moritaa ; Masami Chin-Kanasakia ; Hisazumi Arakia ; Keiji Isshikia ; Shin-ichi Arakia ; Daisuke Koyab ; Masakazu Hanedac ; Atsunori Kashiwagia ; Hiroshi Maegawaa ; Takashi Uzua
- 关键词：AMPK ; AMP-activated protein kinase ; CHOP ; C/EBP homologous protein ; 4E-BP1 ; eukaryotic initiation factor 4E (eIF4E) binding protein 1 ; EPA ; eicosapentaenoic acid ; ER ; endoplasmic reticulum ; FFA ; free fatty acid ; HEK293 ; human embryonic kidney cell line 293 ; LAMP2 ; lysosome-associated membrane protein-2 ; mTORC1 ; mammalian target of rapamycin complex 1 ; PARP ; poly(ADP-ribose) polymerase ; PERK ; PKR-like kinase ; Rheb ; Ras homolog enriched in brain ; RPMI ; Roswell Park Memorial Institute ; TSC1/2 ; tube
- 刊名：Biochimica et Biophysica Acta (BBA)/Molecular Basis of Disease
- 出版年：July 2014
- 年：2014
- 卷：1842
- 期：7
- 页码：1097-1108
- 全文大小：3201 K
文摘
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Saturated FFAs cause podocyte apoptosis, which can be inhibited by unsaturated FFAs.
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Hyperactivation of mTORC1 is involved in saturated FFA-induced podocyte apoptosis.
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ER stress is involved in saturated FFA-mTORC1-related podocyte apoptosis.
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Saturated FFAs activate mTORC1 by enhancing translocation of mTORC1 to lysosome.
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Unsaturated FFAs inhibit saturated FFA-induced translocation of mTORC1 to lysosome.