The SOD mimetic MnL4 reduces toxicity of oxaliplatin (OXA) in cortical astrocytes.
MnL4 prevents the increase in calcium signal induced by OXA in cortical astrocytes.
MnL4 does not reduce OXA toxicity in neuronal and epithelial cancer cell lines.
MnL4 attenuates neuropathic pain induced by OXA in rats.
MnL4 could be used as an adjuvant aid to prevent chemotherapy induced neuropathy.