Neonatal estradiol exposure to female rats changes GABA_A receptor expression and function, and spatial learning during adulthood

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• 作者：Andrea Locci^a ; ¹ ; Patrizia Porcu^b ; ¹ ; Giuseppe Talani^b ; Francesca Santoru^a ; Roberta Berretti^a ; Elisa Giunti^a ; Valentina Licheri^a ; Enrico Sanna^a ; ^b ; Alessandra Concas^a ; ^b ; ^{aconcas@unica.it}
• 关键词：Neonatal estradiol ; GABAA receptor ; Tonic current ; Allopregnanolone ; Hippocampus ; Spatial learning
• 刊名：Hormones and Behavior
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：Complete
• 页码：35-46
• 全文大小：1071 K
• 卷排序：87

文摘

Neonatal estradiol (EB) increases extrasynaptic α4/δ GABAARs in adult hippocampus. Neonatal EB decreases synaptic α1/α4/γ2 GABAAR subunits in adult rat hippocampus. Neonatal EB alters GABAergic tonic and phasic currents in adult rat hippocampus. These changes in GABAARs are independent of ambient allopregnanolone levels. Neonatal EB improves spatial learning and memory retrieval in adult rats.