Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome

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• 作者：Erika Roat ; Nicole Prada ; Roberta Ferraresi ; Chiara Giovenzana ; Milena Nasi ; Leonarda Troiano ; Marcello Pinti ; Elisa Nemes ; Enrico Lugli ; Ornella Biagioni ; et al.
• 关键词：Down syndrome ; Mitochondria ; mtDNA ; Apoptosis
• 刊名：FEBS Letters
• 出版年：2007
• 出版时间：6 February 2007
• 年：2007
• 卷：581
• 期：3
• 页码：521-525
• 全文大小：281 K

文摘

Different types of cells from subjects with Down syndrome (DS) have an increased susceptibility to cell death. We have studied apoptosis and mitochondrial (mt) membrane potential (ΔΨ_m) in peripheral blood mononuclear cells (PBMC) from DS children and age-matched healthy donors after in vitro treatment with apoptogenic molecules, along with mtDNA content. We found that PBMC from DS and healthy controls had a similar tendency to undergo apoptosis and a similar amount of mtDNA. However, in cells from DS subjects, mitochondria showed a higher loss of ΔΨ_m, underlying the presence of an increasing susceptibility of these organelles to damaging agents.