Antidiarrhoeal activity of C. copticum seed extracts at a dose of 100 mg/kg BW was evaluated using experimentally induced castor oil diarrhoea, gastrointestinal transit of charcoal meal and enteropooling activity in male wistar rats and compared to standard drugs.
At a dose of 100 mg/Kg BW (TAQ and TAE) significantly decreased the diarrhoeal droppings in castor oil induced diarrhoea, the mean distance travelled by charcoal meal showed a significant reduction in the secretion of gastrointestinal fluid accumulation by 39.90 % to 50.70 % . C. copticum extracts on castor oil induced fluid accumulation showed a greater inhibitory effect on Na+ levels than on K+ concentrations.
These results suggest that C. copticum seed extracts could be used for the treatment of diarrhoea.