Beryllium in exhaled breath condensate as a biomarker of occupational exposure in a primary aluminum production plant

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• 作者：Sé ; bastien Hulo^a ; ^b ; ^c ; ¹ ; ^{sebastien.hulo@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author} ; ^{sebastien.hulo@chru-lille.fr" class="auth_mail" title="E-mail the corresponding author} ; Anca Radauceanu^d ; ¹ ; ^{anca.radauceanu@inrs.fr" class="auth_mail" title="E-mail the corresponding author} ; Nathalie Ché ; rot-Kornobis^a ; ^b ; ^c ; ¹ ; ^{nathalie.cherot@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author} ; Mike Howsam^e ; ¹ ; ^{michael.howsam@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author} ; Vé ; ronique Vacchina^f ; ¹ ; ^{veronique.vacchina@univ-pau.fr" class="auth_mail" title="E-mail the corresponding author} ; Virginie De Broucker^a ; ^b ; ^c ; ¹ ; ^{virginie.debroucker@chru-lille.fr" class="auth_mail" title="E-mail the corresponding author} ; Davy Rousset^d ; ¹ ; ^{davy.rousset@inrs.fr" class="auth_mail" title="E-mail the corresponding author} ; Michel Grzebyk^d ; ¹ ; ^{michel.grzebyk@inrs.fr" class="auth_mail" title="E-mail the corresponding author} ; Mathieu Dziurla^d ; ¹ ; ^{mathieu.dziurla@inrs.fr" class="auth_mail" title="E-mail the corresponding author} ; Annie Sobaszek^a ; ^b ; ^c ; ¹ ; ^{annie.sobaszek@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author} ; Jean-Louis Edme^a ; ^b ; ^c ; ¹ ; ^{jledme@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ANSES ; Agency for Food ; Environmental and Occupational Health & Safety ; Al ; aluminium ; ACGIH ; American Conference of Governmental Industrial Hygienists ; ANCOVA ; analysis of covariance ; ANOVA ; analysis of variance ; Be ; beryllium ; CHRU ; Centre Hospitalier Ré ; gional Universitaire de Lille ; CBEI ; cumulative beryllium exposure index ; EBC ; exhaled breath condensate ; FVC ; forced vital capacity ; ICP-MS ; inductively coupled plasma mass spectrometer ; IQR ; interquartile range ; LOQ ; limit of quantific
• 刊名：International Journal of Hygiene and Environmental Health
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：219
• 期：1
• 页码：40-47
• 全文大小：633 K

文摘

Low beryllium exposure can induce pulmonary granulomatosis, so called berylliosis. For occupational health monitoring, it is more relevant to assess the internal dose of Be received by the lungs than urinary or atmospheric Be. Exhaled breath condensate (EBC) is a matrix collected non-invasively that derives from the airway lining fluid. EBC beryllium (Be) levels were evaluated as a marker of occupational exposure in a primary aluminum production plant.

Methods

We collected urine and EBC from controls and workers recently exposed to beryllium in the pot room and the anode repair sectors, and calculated a cumulative beryllium exposure index (CBEI) summing the number of years of employment in each task and multiplying by the estimated average beryllium exposure for the task. Concentrations of beryllium and aluminum were measured in EBC (Be-EBC and Al-EBC) and in urine (Be-U and Al-U) by ICP-MS.

Results and conclusion

We have shown that it was possible to measure Be and Al in workers’ EBC. Compared with controls and after adjustment for smoking status, levels of Be-EBC and Al-EBC were higher in pot room workers and exposed subjects, respectively. Due to its relationship with CBEI, but not with Be-U, it appears that Be-EBC could be a promising marker of occupational exposure and provide additional toxicokinetic information in occupational health studies.