Penicillin acylase and O-aryloxycarbonyl hydroxamates: Two acyl-enzymes, one leading to hydrolysis, the other to inactivation
文摘
Potent covalent inhibitors of penicillin acylase. Two orientations of inhibitors binding to the active site. Two distinct acyl-enzyme intermediates, one leading to hydrolysis, the other to enzyme inactivation. Asymmetric carbonates as very versatile enzyme inhibitors.