The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells
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- 作者：Ari Zukerana ; b ; 1 ; Akinori Takahashia ; 1 ; akinori.takahashi@oist.jp" class="auth_mail" title="E-mail the corresponding author ; Shohei Takaokaa ; Haytham Mohamed Aly Mohameda ; Toru Suzukia ; Shinya Ikematsub ; Tadashi Yamamotoa ; tadashi.yamamoto@oist.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：The CCR4-NOT complex ; iPSC ; p21 ; Eomes
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：27 May 2016
- 年：2016
- 卷：474
- 期：2
- 页码：233-239
- 全文大小：1177 K
文摘
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Cnot1 depletion suppresses induction of ALP-positive colonies.
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Down-regulation of Cnot1 suppresses expression of Cnot6/6l/7/8.
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Cnot1 depletion stabilizes p21 and Eomes mRNAs, increasing their expression levels.
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Forced expression of Cnot6/6l/7/8 promotes ALP-positive colony induction from MEFs.
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Cnot6/6l/7/8 overexpression decreases expression of p21 and Eomes mRNAs.