Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils
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- 作者：Mami Tamakia ; Yasunori Konnoa ; Yoshiki Kobayashia ; b ; Masahide Takedaa ; Masamichi Itogaa ; c ; Yuki Moritokia ; Hajime Oyamadaa ; Hiroyuki Kayabaa ; c ; Junichi Chiharaa ; d ; Shigeharu Uekia ; ueki-shige@nifty.com" class="auth_mail
- 关键词：ER ; estrogen receptor ; GPER ; G-protein-coupled estrogen receptor ; EDN ; eosinophil derived neurotoxin
- 刊名：Immunology Letters
- 出版年：July 2014
- 年：2014
- 卷：160
- 期：1
- 页码：72-78
- 全文大小：1460 K
文摘
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Sexual dimorphism in asthma links the estrogen and allergic immune responses.
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GPER, a membrane receptor for estrogen, is expressed in human eosinophils.
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GPER activation regulates chemotaxis and apoptosis of eosinophils.
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Our study suggests that GPER might be a novel regulator of allergic inflammation.