TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation

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• 作者：Smita Yadav¹ ; Juan A. Oses-Prieto² ; Christian J. Peters¹ ; Jing Zhou³ ; Samuel J. Pleasure³ ; Alma L. Burlingame² ; Lily Y. Jan¹ ; Yuh-Nung Jan¹ ; ⁴ ; ^{yuhnung.jan@ucsf.edu}
• 关键词：TAOK2 ; kinase signaling ; Septin7 ; dendritic spine ; chemical genetics ; neurodevelopment ; postsynaptic stability
• 刊名：Neuron
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：93
• 期：2
• 页码：379-393
• 全文大小：5656 K
• 卷排序：93

文摘

TAOK2 is required for spine maturation and postsynaptic Ca+2 compartmentalization TAOK2 phosphorylates the cytoskeletal GTPase Sept7 at the conserved residue T426 Sept7 phosphorylation at T426 by TAOK2 is required for dendritic spine maturation Phosphorylated Sept7 associates with and stabilizes PSD95 promoting spine maturation