Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats
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- 作者：Asheebo Rojas ; arojas@pharm.emory.edu" class="auth_mail" title="E-mail the corresponding author ; Thota Ganesh ; Zahra Manji ; Theon O'neill ; Raymond Dingledine
- 关键词：DFP ; Organophosphate ; Status epilepticus ; Hippocampus ; EP2 receptor ; Novel object recognition ; Light-dark box preference test ; Open field ; Electroencephalography ; Seizure ; Epilepsy ; Anxiety
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：110
- 期：part_PA
- 页码：419-430
- 全文大小：1462 K
文摘
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We investigated cognitive impairment in rats caused by status epilepticus (SE).
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Deficits in a novel object recognition task developed 6–12 weeks after SE.
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Treatment with the EP2 antagonist TG6-10-1 after SE blocked the memory impairment.
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TG6-10-1 did not affect behavioral changes in the light-dark box and open field assays.
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TG6-10-1 is not an acute anticonvulsant as it did not alter acute seizure characteristics.