Epicardium-derived fibroblasts in heart development and disease
详细信息 查看全文
- 作者：Ming Fang ; Fu-Li Xiang ; Caitlin M. Braitsch ; Katherine E. Yutzey<sup> ; sup><sup>katherine.yutzey@cchmc.org" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：MI ; myocardial infarction ; HHD ; hypertensive heart disease ; HI ; hypertensive injury ; ECM ; extracellular matrix ; CF ; cardiac fibroblast ; EMT ; epithelial-to-mesenchymal transition ; EndMT ; endothelial-to-mesenchymal transition ; EPDCs ; epicardium-derived cells
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：23-27
- 全文大小：346 K
文摘
- ss="listitem" id="list_l0005">
- ss="label">•
Fibroblasts derived from embryonic epicardium contribute to cardiac fibrosis.
- ss="label">•
Epicardial developmental pathways are active in adult fibrotic heart disease.
- ss="label">•
Epicardial activation and fibrosis occurs with myocardial infarction.
- ss="label">•
Cardiac fibrosis is differentially localized with ischemic and hypertensive injury.