Changing epidemiology of hepatocellular carcinoma in Asia

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• 作者：George Boon-Bee Goh ; MBBS ; MMed ; MRCP (UK)^a ; ^b ; ^{george.goh.b.b@sgh.com.sg" class="auth_mail" title="E-mail the corresponding author} (Assistant Professor) ; Pik-Eu Chang ; MBBS ; MMed ; MRCP (UK)^a ; ^b ; ^{jason.chang@sgh.com.sg" class="auth_mail" title="E-mail the corresponding author} (Adjunct Assistant Professor) ; Chee-Kiat Tan ; MBBS ; MRCP (UK) ; FRCP (Edinburgh)^a ; ^b ; ^{tan.chee.kiat@sgh.com.sg" class="auth_mail" title="E-mail the corresponding author} (Adjunct Associate Professor)
• 关键词：Hepatocellular carcinoma ; Hepatitis B ; Hepatitis C ; Aflatoxin ; Non-alcoholic steatohepatitis NASH ; Epidemiology
• 刊名：Best Practice & Research Clinical Gastroenterology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：29
• 期：6
• 页码：919-928
• 全文大小：864 K

文摘

Hepatocellular carcinoma is a major problem in Asia because of the presence of multiple risk factors in the region such as endemicity of hepatitis B and significant contamination of foodstuff by aflatoxin in some areas. Another risk factor for HCC, chronic hepatitis C infection, in Asia is most significant in Japan, the only Asian country with more HCV than HBV-related hepatocellular carcinoma. As these risk factors can and are being modified by measures such as universal hepatitis B immunisation, successful treatment of HCV infections, reduction and improved surveillance of aflatoxin contamination of foodstuff, it is not surprising that the epidemiology of HCC in Asia is changing. All these are offset by the rising importance of NAFLD and NASH as chronic liver diseases and risk factors for HCC which contributes to the changing epidemiology of HCC in Asia.