Extent of mossy fiber sprouting in patients with mesiotemporal lobe epilepsy correlates with neuronal cell loss and granule cell dispersion

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• 作者：Barbara Schmeiser^a ; ^{barbara.schmeiser@uniklinik-freiburg.de} ; Josef Zentner^a ; Marco Prinz^b ; Armin Brandt^c ; Thomas M. Freiman^d
• 关键词：Mossy fibers ; Mossy fiber sprouting ; Granule cell dispersion ; Wyler grade ; Seizure outcome
• 刊名：Epilepsy Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：129
• 期：Complete
• 页码：51-58
• 全文大小：1949 K
• 卷排序：129

文摘

Wyler I and II specimen reveal a natural projection of mossy fibers exclusively in CA3 and CA4. Mossy fiber sprouting into the molecular layer and the decrease of mossy fibers in CA4 and CA3, seen in Wyler III and IV, might be due to target cell death in the CA4 and CA3 region. Granule cell dispersion correlated with mossy fiber sprouting and neuronal cell death. The extent of mossy fiber sprouting is correlated to preoperative epilepsy duration. No correlation with postoperative seizure outcome.