Prevalence of epileptiform discharges in healthy 11- and 12-year-old children

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• 作者：Arthur C. Grant^a ; ^{arthur.grant@downstate.edu" class="auth_mail" title="E-mail the corresponding author} ; Larissa Chau^b ; ^{chaularissa@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kapil Arya^a ; ^{kapil.arya@downstate.edu" class="auth_mail" title="E-mail the corresponding author} ; Margaret Schneider^b ; ^{margaret.schneider@uci.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：EEG ; Pediatric ; Centrotemporal ; Generalized spike&ndash ; wave
• 刊名：Epilepsy & Behavior
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：62
• 期：Complete
• 页码：53-56
• 全文大小：666 K

文摘

We sought to determine the prevalence of interictal epileptiform discharges (IEDs) in healthy 11- and 12-year-old children. Sixth grade students with no history of seizure, or neurologic or psychiatric disease, were enrolled in a longitudinal physical activity intervention study. Per study protocol, each student had two EEG recordings approximately 6 months apart. Epileptiform discharges were present in 4 (2.9%) of 140 students: centrotemporal in three and generalized in one. In three children, the discharges were still present six months later. None of the children had developed seizures a minimum of one year after the second EEG. These results are consistent with those of two landmark European studies performed nearly a half century ago, before the modern era of digital EEG. Healthy 11- and 12-year-old children with no history of seizure may have centrotemporal or generalized epileptiform discharges on EEG, which can persist for at least 6 months. Based on both our results and those of the two prior European studies, such discharges, if found incidentally in otherwise healthy children in this age group, should not prompt further evaluation or treatment.