The number of past manic episodes is the best predictor of antidepressant-emergent manic switch in a cohort of bipolar depressed patients
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- 作者：Philip Gorwooda ; b ; Sté ; phane Richard-Devantoyc ; d ; richarddevantoy@orange.fr" class="auth_mail" title="E-mail the corresponding author ; Othman Sentissie ; Yann Le Stratb ; Jean Pierre Olié ; b ; f
- 关键词：Mood stabilizers ; Antidepressive agents ; Bipolar disorder ; Drug therapy ; Switch ; Recurrence
- 刊名：Psychiatry Research
- 出版年：2016
- 出版时间：30 June 2016
- 年：2016
- 卷：240
- 期：Complete
- 页码：288-294
- 全文大小：459 K
文摘
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Association between antidepressant-emergent manic switch and lifetime manic, depressive, and total mood episodes, and with past antidepressant-emergent manic switch.
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Significant association between antidepressant-emergent manic switches and a higher score at pessimistic and suicidal thoughts items of the MADRS.
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A 2.84 fold increased risk of antidepressant-emergent manic switch with having more than four past manic episodes.