文摘
Human bronchial tissue was exposed to whole cigarette smoke in an air-liquid interface three-dimensional co-culture model. Repeated whole cigarette smoke exposure decreased ciliated cell differentiation and altered goblet cell differentiation. Repeated whole cigarette smoke exposure induced secretion of several mediators (IL-8, GRO-α, IL-1β, GM-CSF). Secretion of these mediators was augmented with repetition of the exposure.