miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition
详细信息 查看全文
- 作者：Margherita Puppo1 ; 2 ; 7 ; Gabriele Bucci3 ; 7 ; Martina Rossi1 ; 2 ; Matteo Giovarelli1 ; 9 ; Domenico Bordo1 ; Arfa Moshiri1 ; 6 ; Franco Gorlero4 ; 5 ; Roberto Gherzi1 ; 8 ; roberto.gherzi@hsanmartino.it" class="auth_mail" title="E-mail the corresponding author ; Paola Briata1 ; 8 ; paola.briata@hsanmartino.it" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 July 2016
- 年：2016
- 卷：16
- 期：4
- 页码：967-978
- 全文大小：3607 K
文摘
- •
miR-27b-3p is induced by TGF-β and silences KHSRP in mammary gland cells
- •
KHSRP silencing is required for TGF-β-induced EMT
- •
KHSRP promotes maturation of miR-192-5p that targets a group of EMT factors
- •
KHSRP controls alternative splicing of a set of pre-mRNAs to favor epithelial phenotype