Tamoxifen impairs prepubertal mammary development and alters expression of estrogen receptor α (ESR1) and progesterone receptors (PGR)
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- 作者：H.L.M. Tuckera ; C.L.M. Parsonsa ; S. Ellisb ; M.L. Rhoadsc ; R.M. Akersa ; rma@vt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tamoxifen ; Stem cell ; Mammary ; Steroid receptor
- 刊名：Domestic Animal Endocrinology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：95-105
- 全文大小：1839 K
文摘
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The impact of the ovary and presumably ovarian-derived estrogen prior to puberty is not well defined.
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We evaluated the impact of the antiestrogen tamoxifen on mammary development and expression of ESR1 and PGR in prepubertal heifers.
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Tamoxifen marked reduced mammary development, PGR expression was modestly greater but ESR1 expression was markedly reduced by tamoxifen.
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Putative bovine mammary stem cells (LRC) averaged less than 0.3% of total epithelial cells but were greater after tamoxifen and in the outer region.
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Our findings suggest that expression of ESR1 is especially important in control of prepubertal bovine mammary development.