Mapping and modeling of a strain-specific epitope in the Norwalk virus capsid inner shell
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- 作者：Gabriel I. Parraa ; Stanislav V. Sosnovtseva ; Eugenio J. Abentea ; Carlos Sandoval-Jaimea ; Karin Boka ; Michael A. Dolanb ; Kim Y. Greena ; kgreen@niaid.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Noroviruses ; Epitope-tagging ; Caliciviruses
- 刊名：Virology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：492
- 期：Complete
- 页码：232-241
- 全文大小：8145 K
文摘
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A strain-specific Norwalk virus epitope (NV10) was identified.
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The NV10 epitope was mapped to the inner Shell (S) domain of the VP1.
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The NV10 epitope was linear and transferable into different protein backgrounds.
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Noroviruses have both strain-specific and cross-reactive epitopes in the inner shell that determine antigenicity.