Hippocampal-dependent memory in the plus-maze discriminative avoidance task: The role of spatial cues and CA1 activity
详细信息 查看全文
- 作者：Anderson H.F.F. Leã ; oa ; André ; M. Medeirosc ; Gê ; nedy K.S. Apoliná ; rioa ; Alí ; cia Cabrala ; Alessandra M. Ribeirod ; Flá ; vio F. Barbosab ; Regina H. Silvaa ; c ; reginahsilva@gmail.com" class="auth_mail" title="E-mail the corresponding author ; r.silva@unifesp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：PMDAT ; plus-maze discriminative avoidance task ; EPM ; elevated plus-maze ; %TAV ; percent time in aversive arm ; %TOA ; percent time in open arms ; AV ; aversive arm ; CA1 ; Region 1 of hippocampus ; CA3 ; Region 3 of hippocampus ; DG ; Dentate Gyrus ; BLA ; basolateral amygdala ; GABA ; gamma-aminobutyric acid
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：304
- 期：Complete
- 页码：24-33
- 全文大小：1492 K
文摘
- •
Distal and proximal cues are required to retrieve the discriminative avoidance task.
- •
Proximal cues are more salient than distal cues to spatial discrimination.
- •
Anxiolytic and amnestic effects of muscimol on CA1 are independent.
- •
Muscimol dose-dependently impaired the performance in the avoidance task.
- •
Limited CA1 activity is required to learn the discriminative avoidance task.