Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders

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• 作者：Navya Lakkappa^a ; Praveen T. Krishnamurthy^a ; ^{praveentk7812@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Bruce D. Hammock^b ; D. Velmurugan^c ; M.M. Srinivas Bharath^d
• 关键词：sEH ; soluble epoxide hydrolase ; mEH ; microsomal epoxide hydroxylases ; EETs ; Epoxyeicosatrienoic acids ; PD ; Parkinson&rsquo ; s disease ; SNCA ; synuclein alpha ; LRRK2 ; leucine-rich repeat kinase 2 ; PARK2 ; E3 ubiquitin-protein ligase parkin ; PINK1 ; PTEN induced putative kinase 1 ; DJ-1 ; PARK7 &ndash ; protein deglycase ; ATP13A2 ; ATPase Type 13A2 ; COX ; cyclooxygenase ; LOX ; lipoxygenase ; CYP 450 ; cytochrome P450 ; PLA2 ; phospholipase A2 ; DiHETEs ; dihydroxyeicosatrienoic acids ; ROS ; reactive oxygen species
• 刊名：Medical Hypotheses
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：93
• 期：Complete
• 页码：161-165
• 全文大小：946 K

文摘

Parkinson’s disease (PD) is a multifactorial neurodegenerative disease involving oxidative stress, neuroinflammation and apoptosis. Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites and they play a role in cytoprotection by modulating various cell signaling pathways. This cytoprotective role of EETs are well established in cerebral stroke, cardiac failure, and hypertension, and it is due to their ability to attenuate oxidative stress, endoplasmic reticulum stress, inflammation, caspase activation and apoptosis. The actions of EETs in brain closely parallel the effects which is observed in the peripheral tissues. Since many of these effects could potentially contribute to neuroprotection, EETs are, therefore, one of the potential therapeutic candidates in PD. Therefore, by increasing the half life of endogenous EETs in vivo via inhibition of sEH, its metabolizing enzyme can, therefore, constitutes an important therapeutic strategy in PD.