文摘
LMP2A stimulates the PI3K-dependent activation of BTK to phosphorylate STAT3. The addition of the STAT3 inhibitor, Stattic, blocks the LMP2A-mediated increase in STAT3 phosphorylation and IL-10 production in B cell lymphomas. The BTK inhibitor, Ibrutinib, decreases the LMP2A-dependent increase in IL-10, which may provide a novel therapy for EBV-associated lymphomas.