A feature of synaptic maturation is an activity-dependent switch in the NMDA EPSC decay from slow to fast.
Glutamatergic synapses show NMDA receptor activity from the first postnatal week.
The kinetics of AMPA receptors matures early, whereas developmental changes in NMDA receptor kinetics proceed more gradually.
Rise time kinetics of NMDA-mediated currents appears to mature earlier than decay kinetics.