Regulation of protein kinase C-epsilon and its age-dependence

详细信息    查看全文

• 作者：Chen Kang ; Jingping Qin ; Wil Osei ; Keli Hu ; ^{hu.175@osu.edu}
• 关键词：Protein kinase C ; Mitochondria ; Aging
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1201-1206
• 全文大小：900 K
• 卷排序：482

文摘

Suppressing caveolin-3 expression reduces PKCε targeting to mitochondria by adenosine. PKCε targeting to mitochondria does not require adenosine 2B receptors and PI3 kinase. Adenosine induces an age-related increase in targeting PKCε to mitochondria. Cardiac HSP90 and TOM70 in middle-aged rats is lower than that in young adult rats.