Spatiotemporal control to eliminate cardiac alternans using isostable reduction

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• 作者：Dan Wilson ; ^{dan.d.wilson8@gmail.com} ; Jeff Moehlis
• 关键词：Alternans ; Isostables ; Isostable reduction ; Cardiac arrhythmia ; Optimal control
• 刊名：Physica D: Nonlinear Phenomena
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：342
• 期：Complete
• 页码：32-44
• 全文大小：1375 K
• 卷排序：342

文摘

Isostable reduction (an analog of phase reduction) is applied to PDE models of cardiac dynamics. The reduced systems are analyzed to develop an efficient control strategy for eliminating alternans. The resulting control strategy suppresses alternans using significantly less energy than other control strategies. The feasibility of this control strategy is investigated when the full dynamical equations are unknown.