A pharmacokinetic analysis and dietary information are necessary to confirm or reject the hypothesis on persistent organic pollutants causing type 2 diabetes
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- 作者：Jouko Tuomistoa ; jouko.tuomisto@thl.fi" class="auth_mail" title="E-mail the corresponding author ; j.tuomisto@dnainternet.net" class="auth_mail" title="E-mail the corresponding author ; Riikka Airaksinena ; Hannu Kivirantaa ; Erkki Tukiainenb ; Juha Pekkanena ; c ; Jouni T. Tuomistoa
- 关键词：BMI ; body mass index ; CDD ; chlorinated dibenzo-p-dioxin ; CDF ; chlorinated dibenzofuran ; DDE ; dichlorodiphenyldichloroethylene ; DDT ; dichlorodiphenyltrichloroethane ; Hp ; hepta ; Hx ; hexa ; O ; octa ; PCBs ; polychlorinated biphenyls ; PCDD/Fs ; polychlorinated dibenzo-p-dioxins and dibenzofurans ; Pe ; penta ; POP ; persistent organic pollutants ; T ; tetra ; TCDD ; 2 ; 3 ; 7 ; 8-tetrachlorodibenzo-p-dioxin ; TEF ; toxic equivalency factor ; WHO ; World Health Organization ; WHO-TEQ ; toxic equivalencies according to WHO
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：2 November 2016
- 年：2016
- 卷：261
- 期：Complete
- 页码：41-48
- 全文大小：739 K
文摘
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Dioxins with long half-lives accumulate throughout the entire lifetime.
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Pharmacokinetic models predict the measured concentrations in populations.
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Dioxin concentrations in the body are predicted by age, animal source food and BMI.
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Dioxins may confound the role of ample animal source food in causing diseases.
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Diet and kinetics are vital in claiming causal roles of persistent pollutants in diseases.