Adipokines and endothelial dysfunction in obesity WHO¡ãIII

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• 作者：Christine Bachmayer ; Anne Kemmer ; Nadine Ehrmann ; Till Hasenberg ; Alex ; er Lammert ; Hans-Peter Hammes
• 关键词：AVR ; Arterio-venous-ratio ; CRAE ; Central retinal artery equivalent ; CRVE ; Central retinal vein equivalent ; ED ; Endothelial dysfunction ; hsCRP ; High sensitive CRP ; IGF-BP 3 ; Insulin like growth factor binding protein 3 ; IL-6 ; Interleukin 6 ; MCP-1 ; Monocyte
• 刊名：Microvascular Research
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：89
• 期：Complete
• 页码：129-133
• 全文大小：246 K

文摘

Obesity is closely associated with the metabolic syndrome (MetS) and subsequent low-grade inflammation links to endothelial dysfunction (ED) and cardiovascular disease. The impact of adipokines on retinal ED is not fully understood, in particular not in severe obesity. The aim of the study was to identify the association of the MetS and prespecified adipokines on retinal ED in obesity WHO¡ãIII. 92 obese patients (obesity WHO¡ãIII) were assessed for the MetS (IDF), neck circumference, adipokines and inflammatory markers (hsCRP, TNF¦Á, Il-6, MCP-1, sICAM, sVCAM, IGF-BP3, RBP 4 and adiponectin). Retinal ED as determined by the arterio-venous-ratio (AVR) and retinal vessel diameters (CRAE, CRVE) was measured using retinal photographs. Obese subjects with MetS (MetS + group) differed from the MetS ? by neck circumference, fasting plasma glucose, insulin, HOMA-IR, triglycerides and HDL-C. Importantly, IL-6, sICAM and adiponectin were significantly different between groups, while measures of retinal ED showed no differences. Univariate linear regression revealed a significant association between neck circumference and ED for patients with MetS, and a significant association between adiponectin and CRAE for patients without MetS. This study shows that ED in obesity WHO¡ãIII is independent of MetS or inflammation and that neck circumference has an impact on ED in obesity WHO¡ãIII.