microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma

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• 作者：Shweta Dambal^a ; Angeline A. Giangreco^a ; Andres M. Acosta^a ; Andrew Fairchild^a ; Zachary Richards^a ; Ryan Deaton^a ; Dennis Wagner^c ; Reinhold Vieth^c ; Peter H. Gann^a ; ^b ; Andre Kajdacsy-Balla^a ; ^b ; Theodorus Van der Kwast^d ; Larisa Nonn^a ; ^b ; ^{lnonn@uic.edu}
• 关键词：Vitamin D ; Prostate cancer ; microRNA ; Prostate stroma
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：192-202
• 全文大小：1933 K
• 卷排序：167

文摘

The active hormone 1,25(OH)2D regulates miRs in prostate stroma. Inflammation-related pathways were enriched in the putative targets for the 1,25(OH)2D-regulated miRs. The miR-processing enzyme DICER1 positively correlated with 1,25(OH)2D in the stroma. A high epithelial:stromal ratio of DICER1 protein levels associated with future biochemical recurrence.