Levofloxacin, bismuth, amoxicillin and esomeprazole as second-line Helicobacter pylori therapy after failure of non-bismuth quadruple therapy

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• 作者：Zhiqiang Song^a ; Liya Zhou^a ; ^{zhouliya123456@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jianzhong Zhang^b ; Lihua He^b ; Peng Bai^a ; Yan Xue^a
• 关键词：Bismuth ; Eradication ; Helicobacter pylori ; Levofloxacin ; Non-bismuth quadruple therapy ; Second-line
• 刊名：Digestive and Liver Disease
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：48
• 期：5
• 页码：506-511
• 全文大小：564 K

文摘

The best rescue therapy for Helicobacter pylori (H. pylori) infection following failure of non-bismuth quadruple therapy (NBQT) remains unanswered.

Aims

To determine the efficacy, safety and compliance of levofloxacin, bismuth, amoxicillin and esomeprazole (LBAE) regimen following failure of NBQT.

Methods

132 patients with H. pylori infection refractory to first-line NBQT received LBAE regimen (levofloxacin 500 mg once/day, bismuth potassium citrate 220 mg twice/day, amoxicillin 1000 mg twice/day and esomeprazole 20 mg twice/day for 14 days). Gastric mucosal biopsy was obtained for H. pylori culture, antimicrobial sensitivity test and cytochrome P450 isoenzyme 2C19 polymorphism analysis.

Results

LBAE therapy achieved eradication rates of 73.5% [95% confidence intervals (CI) 65.9–81.1%] in intention-to-treat and 78.5% (71.1–85.9%) in per-protocol analyses in patients with high antibiotic resistance (amoxicillin 8.3%, clarithromycin 55.6%, metronidazole 73.6% and levofloxacin 36.1%). Adverse effects were found in 19.2% and compliance in 96.1% of the treated patients. Multivariate analyses identified levofloxacin resistance [odds ratio (OR) 7.183, 95% CI 1.616–31.914, P = 0.010] and history of quinolone intake (4.844, 1.174–19.983, P = 0.029) as independent predictors of treatment failure. The eradication rate of patients with dual amoxicillin and levofloxacin resistance was significantly decreased (33.3%, P = 0.006).

Conclusions

In populations with high levofloxacin resistance, 14-day second-line LBAE regimen resulted in an unsatisfactory efficacy in patients resistant to NBQT despite good safety and compliance.