The relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use

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• 作者：Sun Gyo Lim^a ; ¹ ; Rae Woong Park^b ; ¹ ; Sung Jae Shin^a ; Dukyong Yoon^b ; Joon Koo Kang^a ; Jae Chul Hwang^a ; Soon Sun Kim^a ; Jin Hong Kim^a ; Kee Myung Lee^a ; ^{lkm5104@aumc.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Clarithromycin ; Drug resistance ; Helicobacter pylori ; Macrolides ; Microbial
• 刊名：Digestive and Liver Disease
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：48
• 期：4
• 页码：385-390
• 全文大小：676 K

文摘

The previous use of antibiotics is known to correlate positively with antibiotic resistance; whether this is also the case in the eradication of Helicobacter pylori infection is unclear.

Aim

To investigate the relationship between the previous use of antibiotics and the failure of eradication therapy in H. pylori infection.

Methods

The relationship between the clinical parameters and the failure of H. pylori eradication was analyzed in patients administered standard triple therapy and then assessed for the eradication of H. pylori based on a C13-urea breath test.

Results

In a multivariate analysis, failure rates increased significantly in patients with a history of clarithromycin (odds ratio [OR], 4.445) or other macrolides (OR, 2.407) use, who were female (OR, 1.339), or who were older than 60 years of age (OR, 1.326). The eradication failure rate in patients with a history of macrolides use for >2 weeks was significantly higher than if the duration of use was <2 weeks (44.8% vs. 29.3%, p = 0.047).

Conclusions

A patient's history of macrolides is a useful predictor of the likelihood of standard triple therapy failure in H. pylori eradication. The alternatives such as a bismuth-based quadruple or a levofloxacin-containing therapy should be considered in patients treated with macrolides for >2 weeks.