Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis

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• 作者：Malena Cohen-Cymberknoh^a ; ¹ ; Noa Gilead^b ; ¹ ; Silvia Gartner^c ; Sandra Rovira^c ; Hannah Blau^d ; Huda Mussaffi^d ; Joseph Rivlin^e ; Michal Gur^e ; Michal Shteinberg^e ; Lea Bentur^f ; Galit Livnat^f ; Micha Aviram^g ; Elie Picard^h ; Ariel Tenenbaumⁱ ; Shoshana Armoni^a ; Oded Breuer^a ; David Shoseyov^a ; Eitan Kerem^a
• 关键词：Cystic fibrosis ; Pseudomonas infection ; Eradication failure
• 刊名：Journal of Cystic Fibrosis
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：15
• 期：6
• 页码：776-782
• 全文大小：368 K
• 卷排序：15

文摘

Eradication of Pseudomonas aeruginosa (PA) is critical in cystic fibrosis (CF) patients.ObjectivesTo determine eradication success rate of newly acquired PA and to identify characteristics associated with eradication failure.MethodsIn an observational study, data from patients with newly acquired PA infection from 2007 to 2013 were collected. Clinical variables were compared in patients with and without successful eradication for ≥ 1 year.ResultsOf 183 patients out of 740 (25%) from 7 CF Centers that had newly acquired PA, eradication succeeded in 72%. Patients with the highest risk of failure had multi-resistant PA, fewer sputum cultures taken, were older, and were diagnosed at a later age. The risk of eradication failure increased by 1.3% with each year of delayed CF diagnosis; successful eradication increased by 17% with each additional sputum culture taken.ConclusionsDelayed detection of PA infection leading to delayed treatment and growth of multi-resistant organisms is associated with eradication failure.