Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area

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• 作者：Marco Albonico ; Peter G. Smith ; Elena Ercole ; Andrew Hall ; Hababu M. Chwaya ; Kassim S. Alawi ; Lorenzo Savioli
• 刊名：Transactions of the Royal Society of Tropical Medicine and Hygiene
• 出版年：1995
• 出版时间：September - October 1995
• 年：1995
• 卷：89
• 期：5
• 页码：538-541
• 全文大小：475 K

文摘

The comparative efficacy of albendazole and mebendazole in the treatment of intestinal nematode infections were compared 3 weeks after treatment in a randomized trial among schoolchildren on Pemba Island, Tanzania. Egg counts were compared 3 weeks, 4 months and 6 months after treatment of 731 children seen on each occasion. Differences in the efficacies were apparent with some nematodes 21 d after treatment, but these were no longer apparent 4 months after treatment, and by 6 months intensities of infection were similar to pre-treatment levels. These findings suggest that treatment of schoolchildren every 4 months may be necessary in this highly endemic area in order to have an impact on the intensity of intestinal nematode infections sufficient to be likely to reduce morbidity.