Expression changes of genes associated with apoptosis and survival processes in Parkinson’s disease
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- 作者：Nazli Yalç ; ınkayaa ; 1 ; Hazal Hayturala ; 1 ; Başar Bilgiç ; b ; Ö ; zkan Ö ; zdemirc ; Haşmet Hanağasıb ; Cem İsmail Kü ; ç ; ü ; kalia ; Zeynep Ö ; zbekd ; Uğur Akcana ; Halil Atilla İdrisoğluc ; Hakan Gü ; rvitb ; Erdem Tü ; zü ; na ; drerdem@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson&rsquo ; s ; disease ; Apoptosis ; Survival ; Akt ; Real time PCR
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：26 February 2016
- 年：2016
- 卷：615
- 期：Complete
- 页码：72-77
- 全文大小：819 K
文摘
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Anti-apoptotic PI3K/Akt pathway factors are overexpressed in PBMC of PD patients.
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PD patients with postural instability show reduced anti-apoptotic factor expression.
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Survival gene expression profiles of mice and patients with PD show resemblance.
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PBMC expression levels of AIFM1 might serve as a biomarker of disability in PD.