The Sertoli cell hormones inhibin-B and anti Müllerian hormone have different patterns of secretion in prepubertal cryptorchid boys

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• 作者：Dina Cortes^a ; ^b ; ^c ; Erik Clasen-Linde^d ; John M. Hutson^e ; ^f ; ^g ; Ruili Li^e ; Jorgen Thorup^a ; ^c ; ^{Jorgen.Mogens.Thorup@regionh.dk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cryptorchidism ; Inhibin-B ; Anti-Mü ; llerian hormone ; Luteinizing hormone ; Follicle stimulation hormone ; Sertoli cells
• 刊名：Journal of Pediatric Surgery
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：51
• 期：3
• 页码：475-480
• 全文大小：909 K

文摘

The Sertoli-cells produce inhibin-B and Anti-Müllerian-Hormone (AMH). Much is still unknown about these hormones in prepubertal cryptorchids. The Sertoli-cells are mandatory for germ cell development. The aim of the study was to investigate if there are differences in secretion pattern of Sertoli-cell hormones and their gonadotropin feed-back mechanisms.

Methods

Included were 94 prepubertal cryptorchid boys 0.5–13.1 years with measurements of serum-inhibin-B, Anti-Müllerian-Hormone (AMH), Luteinizing Hormone (LH) and Follicle Stimulation Hormone (FSH). The serum values were measured using commercially available kits. The hormonal values were related to age-matched normal values. Testicular biopsy was taken at orchiopexy.

Results

Inhibin-B positively correlated to AMH for 1–13 year-old patients (p < 0.0001), but not for 0.5–1 year-old patients (p = 0.439). For 0.5–1 year-old patients inhibin-B-values tended to decrease (p = 0.055), in contrast to AMH-values (p = 0.852).

LH was elevated more often than FSH (p = 0.014). FSH and LH were positively associated in patients both 0.5–1 year (p = 0.042) and 1–13 years of age (p < 0.0001). LH correlated positively to inhibin- B (p = 0.001). In contrast, FSH did not correlate to inhibin-B or AMH (p = 0.755 and p = 0.528). The number of A-dark spermatogonia per tubular transverse section was positively correlated to inhibin-B serum level.

Conclusion

Our new finding of an association between LH and inhibin-B in infancy of cryptorchid boys may be essential for the transformation of gonocytes to A-dark spermatogonia. Previously, LH associated to inhibin-B was described in early puberty only. During the first year of life inhibin-B values decreased faster than AMH. The AMH-levels may just reflect the increased Sertoli cell number that occurs during the first 3 months of life.