Negative Association of Testosterone on Spatial Visualization in 35 to 80 Year Old Men

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• 作者：Julie E. Yonker ; Elias Eriksson ; Lars-Gö ; ran Nilsson ; Agneta Herlitz
• 关键词：testosterone ; visuospatial ability ; steroid hormones ; cognition ; aging
• 刊名：Cortex
• 出版年：2006
• 出版时间：2006
• 年：2006
• 卷：42
• 期：3
• 页码：376-386
• 全文大小：144 K

文摘

Androgens have been linked to visuospatial ability. We examined the relationship between serum free testosterone (T) levels and spatial visualization ability in a population-based sample of 450 healthy men between the ages of 35 and 80 years. They were tested on block design and Mini Mental State Examination (MMSE) draw-a-figure, as well as tasks assessing episodic memory, semantic memory, procedural memory, and verbal fluency. Blood was analyzed for free T and estradiol. Participants were grouped into high or low free T based on age-specific median values. Participants with low free T performed at a superior level on both the block design task and draw-a-figure task as compared to participants with high free T. The results are discussed within the scant body of research on androgens and cognition in men.