Fluid shear stress suppresses TNF-α-induced apoptosis in MC3T3-E1 cells: Involvement of ERK5-AKT-FoxO3a-Bim/FasL signaling pathways
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- 作者：Geng Bina ; b ; Zhang Boa ; b ; Wang Jinga ; b ; Jiang Jina ; b ; Tan Xiaoyia ; b ; Chen Conga ; b ; An Lipinga ; b ; Ma Jinglina ; b ; Wang Cuifanga ; b ; Chen Yongganga ; b ; Xia Yayia ; b ; xiayayildey@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fluid shear stress ; Extracellular signal-regulated kinase 5 ; Forkhead box O 3a ; FasL ; Bim ; Osteoblasts
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：343
- 期：2
- 页码：208-217
- 全文大小：2222 K
文摘
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Fluid shear stress inhibits osteoblast apoptosis induced by TNF-α.
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Inhibition of ERK5 activity by transfection of ERK5 siRNA blocks FSS-mediated anti-apoptotic effect in osteoblast.
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Activated ERK5-AKT-FoxO3a-Bim/FasL signaling pathways by FSS is required to protect osteoblast from apoptosis.