The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65
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- 作者：Corina Hutterera ; Ina Niemanna ; Jens Milbradta ; Tony Frö ; hlichb ; Christoph Reiterb ; Onat Kadiogluc ; Hanife Bahsia ; Isabel Zeitträ ; gera ; Sabrina Wagnera ; Jü ; rgen Einsiedeld ; Peter Gmeinerd ; Nico Vogele ; Sebastian Wandingerf ; Klaus Godlf ; Thomas Stammingera ; Thomas Efferthc ; Svetlana B. Tsogoevab ; Manfred Marschalla ; manfred.marschall@viro.med.uni-erlangen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human cytomegalovirus ; Artesunate and chemical derivatives ; Broad antiviral activity ; Increase of antiviral efficacy ; Binding of artesunate to NF-κB RelA/p65 ; Interference with NF-κB signaling pathways
- 刊名：Antiviral Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：124
- 期：Complete
- 页码：101-109
- 全文大小：1882 K
文摘
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Artesunate (ART) exerts strong and broad antiviral activity.
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Induction of ART resistance of HCMV was not observed in vitro.
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Upregulation of NF-κB signaling in reporter cell clones and HCMV-induced NF-κB promoter activity was inhibited by ART.
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NF-κB p65 was captured by immobilized ART and ART-binding peptides within p65 were suggested by mass spectrometry.
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Chemical derivatives of ART including trimers and dimers showed enhanced anti-HCMV activity.