The role of iron in mitochondrial function

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• 作者：Sonia Levi ; Ermanna Rovida
• 关键词：Mitochondria ; Iron ; Iron– ; sulfur cluster ; Heme ; Mitochondria iron overload diseases
• 刊名：Biochimica et Biophysica Acta (BBA)/General Subjects
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：1790
• 期：7
• 页码：629-636
• 全文大小：391 K

文摘

Background

Iron is an essential element for life, as it is a cofactor for enzymes involved in many metabolic processes, but it can also be harmful, since its excess is thought to enhance the production of reactive oxygen species and induce oxidative damage. Iron is transformed into its biologically available form in the mitochondrion by the iron–sulfur (Fe/S) cluster and heme synthesis pathways. During the past decade, substantial progress has been made in the elucidation of iron-linked mechanisms that occur in the mitochondrion, demonstrating the crucial role played by this organelle in maintaining cellular iron homeostasis.

General Significance

This review summarizes current knowledge of the mechanisms underlying iron trafficking in mitochondria and how it is handled inside the organelle. Relevant updates with regard to the Fe/S cluster and heme biosynthetic pathways, as well as the relationship between mitochondrial iron homeostasis impairment and related diseases, are also discussed.