Goniothalamin prevents the development of chemically induced and spontaneous colitis in rodents and induces apoptosis in the HT-29 human colon tumor cell line
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- 作者：Dé ; bora Barbosa Vendramini-Costaa ; b ; 1 ; vendramini.debora@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Antonio Alcaidec ; 1 ; Karin Juliane Pelizzaro-Rochad ; 1 ; Elena Taleroc ; Javier Á ; vila-Romá ; nc ; Sofia Garcia-Mauriñ ; oe ; Ronaldo Aloise Pillia ; Joã ; o Ernesto de Carvalhob ; f ; Virginia Motilvac
- 关键词：Goniothalamin ; HT-29 cells ; Apoptosis ; Colitis ; IL-10 deficient mice ; Chronic inflammation
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：300
- 期：Complete
- 页码：1-12
- 全文大小：1660 K
文摘
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Goniothalamin (GTN) inhibits the development of TNBS-induced colitis in rats.
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Moreover, GTN prevents the development of spontaneous colitis in IL-10 deficient mice.
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This activity relies on downregulation of TNF-α and upregulation of SIRT-1 expression.
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GTN induces intrinsic apoptosis in HT-29 cells, involving ROS, MAPK and caspases.
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These results highlight GTN as a potential chemopreventive agent for colon cancer.