The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats
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- 作者：Ernesto Martí ; nez-Martí ; neza ; Cristina Rodrí ; guezb ; Marí ; a Galá ; nb ; Marí ; a Mianaa ; Raquel Jurado-Ló ; peza ; Marí ; a Visitació ; n Bartolomé ; c ; Marí ; a Luacesd ; Fabiá ; n Islasd ; José ; Martí ; nez-Gonzá ; lezb ; Natalia Ló ; pez-André ; se ; Victoria Cachofeiroa ; vcara@ucm.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fibrosis ; Leptin ; Lysyl oxidase ; Obesity
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：96-104
- 全文大小：1425 K
文摘
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LOX is overexpressed in the heart and aorta from obese rats.
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LOX inhibition attenuates fibrosis in obese rats in the cardiovascular system.
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Leptin induces LOX expression in cardiac myofibroblasts and VSMCs.
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LOX inhibition limits the profibrotic and prooxidant effects of leptin in cells.