The characterisation of LATS2 kinase regulation in Hippo-YAP signalling
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- 作者：Lily Hoa1 ; Yavuz Kulaberoglu1 ; Ramazan Gundogdu ; Dorthe Cook ; Merdiye Mavis ; Marta Gomez ; Valenti Gomez ; Alexander Hergovich ; a.hergovich@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：LATS2 ; large tumour suppressor 2 ; MST1/2 ; mammalian serine/threonine Ste20-like kinases 1/2 ; MOB ; Mps one binder ; NDR ; nuclear Dbf2-related ; NTR ; N-terminal regulatory region ; HM ; hydrophobic motif ; PIF ; PDK1-interacting fragment ; PRK2 ; PKC related kinase 2 ; STK ; serine/threonine kinase ; YAP1 ; yes-associated protein 1 ; wt ; wild-type ; kd ; kinase-dead
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：28
- 期：5
- 页码：488-497
- 全文大小：1245 K
文摘
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LATS2 activity depends on Ser872 and Thr1041 phosphorylation in the T-loop and HM.
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The Hippo kinases MST1/2 phosphorylate LATS2 on Thr1041 in the HM, but not Ser872.
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LATS2 activation requires binding of MOB1 to the N-terminal regulatory region.
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Constitutively hyperactive LATS2-PIF functions independently of MOB1 binding.
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LATS2-PIF phosphorylates and inhibits YAP1 independently of stable YAP1 binding.