Role of mTOR in glioblastoma

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• 作者：Zekeriya Duzgun ; Zuhal Eroglu ; Cigir Biray Avci
• 关键词：mTOR ; mammalian target of rapamycin ; mTOR ; mammalian target of rapamycin ; PI3K ; phosphoinositide 3-kinase ; RICTOR ; rapamycin-insensitive companion of mTOR ; RAPTOR ; regulatory-associated protein of mTOR ; mTORC1 ; mammalian target of rapamycin complex 1 ; DEPTOR ; DEP domain-containing mTOR-interacting protein ; FKBP12 ; FK506-binding intracellular protein ; TSC1 ; Tuberous sclerosis complex 1 ; TSC2 ; tuberous sclerosis complex 2 ; Akt ; Protein kinase B ; PDK1 ; Pyruvate dehydrogenase lipoamide kinase isozym
• 刊名：Gene
• 出版年：2016
• 出版时间：10 January 2016
• 年：2016
• 卷：575
• 期：2
• 页码：187-190
• 全文大小：363 K

文摘

Mammalian target of rapamycin (mTOR), which is a member of the serine/threonine protein kinase family, is a protein complex that has a central role of cell growth and proliferation. mTOR emerges as a critical cell growth checkpoint on phosphoinositide 3-kinase (PI3K) signaling pathway. In this case mTOR has become an important therapeutic target for glioblastoma (GBM) that is one of the most deadly types of cancer. Various combination treatments including inhibition of mTOR may provide more significant results in the treatment of GBM. In addition to new mTOR targets, which may have a plant origin form, more potent mTOR inhibitors by utilizing the computational methodology may emerge as a hope for GBM therapy. In the future, a better understanding of the functional properties of mTORC2 with its potent effective inhibitors may help design more efficiently GBM treatment modalities.